He worked in several TV productions as in the Fallen, mini-series (2007). One of his best known works is important Vampire Diaries (2009). For Vampires Diaries he auditioned for the two main characters, brothers Damon and Stefan, determined that it was better for the role of Stefan. For season 5 of Vampire Diaries began directing and acting in the same show. He has also worked in other TV productions and movies such as: Wolf Lake, The Bayton Outlaws, Mother’s Day and The Late Bloomer, Peaceful Warriors, Shot in the Heart, among others.
He also stood out as producer and actor in the film Before I disappear (2014) where he plays Gideon, which won the SXSW Film festival Audience Award and competed in the Venice Film Festival. For that same year he co-started in the movie Amira & Sam where he plays Charlie. He is currently working on a play called “Cal in Camo” as Flynt. The play is about a couple who recently had their first daughter, and are facing problems in their lives and relationship, until her brother, Flynt (Paul Wesley) arrives to live with them for a while, after having lost her wife in a flood. For Wesley, theater to television and film work is a completely different transition. He does not rule out the option of directing in the field of theater, but understands that he has to acquire more experience in the theater before occupying that role.